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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2011; 17(9): 1152-1159
Published online Mar 7, 2011. doi: 10.3748/wjg.v17.i9.1152
Published online Mar 7, 2011. doi: 10.3748/wjg.v17.i9.1152
Tumor behavior | HepG2 | HepG2.2.15 | ||
Cell injection (n = 10) | Tissue implantation (n = 10) | Cell injection (n = 10) | Tissue implantation (n = 10) | |
Formation (%) | 100 | 100 | 10d | 40a |
Volume (cm3) | 3.1 ± 1.1 | 1.7 ± 0.4 | 2.1 | 2.3 ± 0.3 |
Growth | Expensive growth and central necrosis | Same | Same | Same |
Surrounding tissue | Degeneration and necrosis | Same | Same | Same |
Normal tissue | Spotty or piecemeal necrosis, scattered fat droplets and vacuolation, focal inflammatory infiltration | Spotty or piecemeal necrosis, diffuse fatty change 40% and focal inflammatory infiltration | Spotty or piecemeal necrosis, diffuse or scattered fatty change 50%, focal inflammatory infiltration and diffuse cytoplasmic swelling of liver cells | Spotty or piecemeal necrosis, diffuse fatty change 40%, focal inflammatory infiltration and mild cytoplasmic swelling of liver cells |
Tumor invasion | Abdominal wall 100%; pancreas 37.5%; esophago 12.5% | Abdominal wall 50%; pancreas 12.5%; diaphragma/ribs 10% | Abdominal wall 10% | Diaphragma/ribs 10% |
Metastasis | ||||
Intra-liver | 75% (6/8) | 30% (3/10) | 0 | 0 |
Lung | 50% (4/8) | 0 | 10% (1/10) | 10% (1/10) |
- Citation: Zhao R, Wang TZ, Kong D, Zhang L, Meng HX, Jiang Y, Wu YQ, Yu ZX, Jin XM. Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2. World J Gastroenterol 2011; 17(9): 1152-1159
- URL: https://www.wjgnet.com/1007-9327/full/v17/i9/1152.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i9.1152