Original Article
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Mar 7, 2011; 17(9): 1152-1159
Published online Mar 7, 2011. doi: 10.3748/wjg.v17.i9.1152
Table 1 Pathological analysis in vivo
Tumor behaviorHepG2
HepG2.2.15
Cell injection (n = 10)Tissue implantation (n = 10)Cell injection (n = 10)Tissue implantation (n = 10)
Formation (%)10010010d40a
Volume (cm3)3.1 ± 1.11.7 ± 0.42.12.3 ± 0.3
GrowthExpensive growth and central necrosisSameSameSame
Surrounding tissueDegeneration and necrosisSameSameSame
Normal tissueSpotty or piecemeal necrosis, scattered fat droplets and vacuolation, focal inflammatory infiltrationSpotty or piecemeal necrosis, diffuse fatty change 40% and focal inflammatory infiltrationSpotty or piecemeal necrosis, diffuse or scattered fatty change 50%, focal inflammatory infiltration and diffuse cytoplasmic swelling of liver cellsSpotty or piecemeal necrosis, diffuse fatty change 40%, focal inflammatory infiltration and mild cytoplasmic swelling of liver cells
Tumor invasionAbdominal wall 100%; pancreas 37.5%; esophago 12.5%Abdominal wall 50%; pancreas 12.5%; diaphragma/ribs 10%Abdominal wall 10%Diaphragma/ribs 10%
Metastasis
Intra-liver75% (6/8)30% (3/10)00
Lung50% (4/8)010% (1/10)10% (1/10)