Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells

Figure 6 Oral administration of cinnamon extract ameliorates experimental colitis. Mice were orally fed with PBS or cinnamon extract (CE) (50 μg/g per day) for 20 d, and intestinal colitis was induced by intrarectal injection of TNBS (50 μg/g in 50% ethanol). A: A change in body weight was monitored for 5 d; B: Gross intestinal changes were analyzed with a magnifying glass 3 d after colitis induction; C: After HE staining, histological analysis was performed by comparing colon sections of treatment groups; D: After induction of inflammatory bowel disease, cyclooxygenase (COX)-2 expression in mesenteric lymph nodes was compared by quantitative real-time PCR and immunoblotting; E: Expression levels of cytokines in mesenteric lymphocytes were measured by quantitative real-time PCR; F: Intracellular protein levels of interleukin (IL)-10 and tumor necrosis factor (TNF)-α were measured by flow cytometry. Error bars indicated SD. ^bP < 0.005, ^cP < 0.001. Data are representative of three independent experiments. IFN: Interferon.