Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells

Figure 5 Cinnamon-extract-treated dendritic cells inhibit Th1 polarization. CD11c⁺ dendritic cells (DCs) were pre-pulsed with lipopolysaccharide (LPS) alone or in combination with cinnamon extract (CE) (0.2 mg/mL) for 24 h. Then, they were co-cultured with CD4⁺ T cells isolated from Do11.10 mice. A: After 72 h co-culture, CD4⁺ T cells were re-isolated from each treatment group and relative expression levels of cytokine mRNA were measured by quantitative real-time PCR; B: Intracellular protein levels of interleukin (IL)-10 and interferon (IFN)-γ in CD4⁺ T cells in each treatment group was analyzed by flow cytometry. Error bars indicated SD. ^aP < 0.05, ^bP < 0.005, ^cP < 0.001. Data are representative of three independent experiments.