Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells

Figure 3 Treatment of cinnamon extract inhibits maturation of CD11⁺ dendritic cells. CD11⁺ dendritic cells (DCs) were stimulated in the absence or presence of cinnamon extract (CE) and expression levels of cytokines [interleukin (IL)-1β, IL-4, IL-6, IL-10, IL-12, interferon (IFN)-γ, tumor necrosis factor (TNF)-α and transforming growth factor (TGF)-β] (A) and co-stimulatory molecules (B7.1, B7.2, ICOS ligand, B7-DC and MHCII) (B) were measured by quantitative real-time PCR. Effect of cinnamon extract (CE) treatment on cyclooxygenase (COX)-2 expression at the RNA (C) and protein (D) level was measured by quantitative real-time PCR and immunoblotting, respectively. Error bars indicated SD. ^aP < 0.05, ^bP < 0.005, ^cP < 0.001. Data are representative of three independent experiments.