miR-200 family expression is downregulated upon neoplastic progression of Barrett’s esophagus

Table 2 Top molecular and cellular functions of miR-200 gene targets

miRNA	Molecular and cellular functions	Molecules involved	P value
	Cell cycle	41	1.90E-07-2.82E-02
	Gene expression	53	4.94E-07-2.82E-02
miR-141	Cellular movement	39	2.45E-05-2.82E-02
	Cellular assembly and organization	61	2.88E-04-2.82E-02
	Cellular growth and proliferation	68	2.88E-04-2.28E-02
	Gene expression	84	1.37E-09-2.32E-02
	Cellular growth and proliferation	108	5.65E-05-2.32E-02
miR-200c	Cell cycle	53	9.17E-05-2.32E-02
	Cell death	95	9.62E-05-2.32E-02
	Cellular assembly and organization	55	1.19E-04-2.32E-02

The top five functions associated with the predicted targets of miR-141 and miR-200c, as determined by Ingenuity Pathway Analysis, are shown in this table. This analysis used a right-tailed Fisher’s exact test to calculate the probability (P value above) that each cellular function ascribed to the predicted target gene list was due to chance alone. For each miRNA, the molecular and cellular functions are ranked according to their P value.