miR-200 family expression is downregulated upon neoplastic progression of Barrett’s esophagus

Table 1 Relative miRNA expression in Barrett’s esophagus, gastric and duodenal mucosal tissues

MiRNA	Duodenal (n = 10)	Barrett’s esophagus (n = 17)	Gastric (n = 15)	P value (Kruskal-Wallis test)
miR-141	0.076 (0.039,0.167)	0.026 (0.023, 0.036)	0.051 (0.042, 0.092)	0.000212
miR-200a	0.148 (0.067, 0.340)	0.148 (0.126, 0.177)	0.247 (0.154, 0.509)	0.03142
miR-200b	0.796 (0.606, 1.276)	0.833 (0.750, 0.993)	1.233 (1.089, 1.963)	0.00112
miR-200c	2.700 (1.890, 3.511)	1.049 (0.929, 1.170)	2.335 (1.792, 2.773)	< 0.000112
miR-429	0.095 (0.042, 0.070)	0.070 (0.061, 0.087)	0.078 (0.072, 0.153)	0.259

Relative expression for each epithelial tissue type. Relative expression values are median (95% CI). The group P value was the result of a Kruskal-Wallis test across the three tissue groups. Significant differences were identified by post hoc testing by the Holm-Bonferroni method for:

¹Duodenal versus Barrett’s esophagus mucosa - miR-141 (P = 0.0008) and miR-200c (P < 0.0001);

²Gastric versus Barrett’s esophagus mucosa - miR-141 (P = 0.0004) miR-200a (P = 0.0078), miR-200b (P = 0.0001), and miR-200c (P < 0.0001).