Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

Table 3 Analysis of factors affecting development of hepatocellular carcinoma at older age (over 80 yr old)

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
Sex
Female	1			1
Male	0.45	0.229-0.867	0.017	0.47	0.200-1.119	0.089
BMI
<25	1			1
≥ 25	0.49	0.201-1.201	0.119	0.48	0.174-1.321	0.155
Diabetes mellitus
Without	1			1
With	0.23	0.054-0.957	0.043	0.32	0.074-1.412	0.133
Smoking (packs year)
< 20	1			1
≥ 20	0.58	0.270-1.258	0.169	0.81	0.306-2.164	0.680
Alcohol (g/d)
< 60	1			1
≥ 60	0.72	0.167-3.118	0.663	0.45	0.056-3.606	0.451
Total bilirubin (mg/dL)
< 2.0	1			1
≥ 2.0	1.00	-	0.97	1.00	-	0.98
Prothrombin activity (%)
≥ 70	1			1
< 70	0.10	0.014-0.755	0.025	0.15	0.020-1.166	0.07
Platelet (× 104/μL)
≥ 10	1			1
< 10	0.54	0.275-1.076	0.080	0.62	0.287-1.360	0.236
ALT (IU/L)
< 80	1			1
≥ 80	0.10	0.024-0.427	0.002	0.13	0.030-0.569	0.007
GGT (IU/L)
< 50	1			1
≥ 50	0.51	0.262-0.984	0.045	1.01	0.479-2.146	0.971

HR: Hazard ratio; BMI: Body mass index; ALT: Alanine aminotransferase; GGT: γ-glutamyl transpeptidase.