Body mass index is associated with age-at-onset of HCV-infected hepatocellular carcinoma patients

Table 1 Clinical characteristics of patients classified with hepatocellular carcinoma occurrence age

Factors	Occurrence age of HCC (years old)			P
	<60 (n = 79)	60-80 (n = 439)	≥80 (n = 38)
Sex
Male/Female, n	70/9	264/175	17/21	< 0.0001a
BMI (kg/m2)	23.8 ± 3.4	22.9 ± 3.4	21.8 ± 3.3	0.02b
< 25/25 <, n	50/29	325/114	32/6	0.039a
Diabetes mellitus
With/without, n	16/63	86/353	2/36	0.088a
Smoking (pack years)
< 20/≥ 20, n	43/36	137/302	9/29	0.0001a
Alcohol consumption (g/d)
< 60/≥ 60, n	65/14	416/23	36/2	< 0.0001a
Tumor stage
I/II/III, n	21/33/25	116/196/127	11/16/11	0.981a
Child-Pugh class
A/B/C, n	55/23/1	349/87/3	34/4/0	0.145a
Albumin (g/dL)	3.57 ± 0.53	3.64 ± 0.50	3.63 ± 0.41	0.586b
< 3.5/≥ 3.5, n	30/49	151/288	14/24	0.433a
Total bilirubin (mg/dL)	1.23 ± 0.62	1.05 ± 0.55	0.80 ± 0.30	0.0002b
< 2.0/≥ 2.0, n	70/9	413/26	38/0	0.047a
Prothrombin activity (%)	76.1 ± 16.6	79.9 ± 15.1	89.1 ± 12.2	0.0002b
< 70/≥ 70, n	26/53	98/341	3/35	0.003a
Platelet count (× 104/μL)	10.4 ± 7.8	11.0 ± 5.5	13.1 ± 5.8	0.005b
< 10/≥ 10, n	45/34	223/216	14/24	0.125a
ALT (IU/L)	78.3 ± 39.3	71.8 ± 44.1	41.7 ± 19.3	< 0.0001b
< 80/≥ 80, n	47/32	288/151	36/2	0.0004a
GGT (IU/L)	123.7 ± 102.5	86.0 ± 86.6	54.6 ± 36.1	< 0.0001b
< 50/≥ 50, n	15/64	173/266	20/18	0.0002a

Continuous variables are expressed as mean ± standard deviation. Statistical analysis was done using a: the χ² test or b: the Turkey-Kramer test. HCC: Hepatocellular carcinoma; BMI: Body mass index; ALT: Alanine aminotransferase; GGT: γ-glutamyl transpeptidase.