Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

Table 5 Summary of the performance characteristics of serum tumor markers for the diagnosis of pancreatic cancer

Serum tumor marker	Author	Yr	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)
CA19-9	Boeck et al[141]	2006	70-90	43-91	72	81	67
	Ni et al[142]	2005
	Steinberg et al[143]	1990
	Safi et al[144]	1997
	Mu et al[162]	2003
CEA in pancreatic juice	Ozkan et al[155]	2003	NA	NA	77	95	85
	Futakawa et al[154]	2000
	Ni et al[142]	2005
CEA in serum	Boeck et al[141]	2006	45	75	NA	NA	NA
CA19-9 + CEA	Ni et al[142]	2005	37	84	91	90	89
	Ozkan et al[155]	2003
	Ma et al[163]	2009
CA 242	Nilsson et al[160]	1992	60	76	63	61	71
	Röthlin et al[164]	1993
	Carpelan-Holmström et al[165]	2002
	Pålsson et al[166]	1993
CEA + CA 242	Ni et al[142]	2005	34	92	67	90	87
	Ozkan et al[155]	2003
	Hall et al[167]	1994
CA19-9 + CA 242	Ni et al[142]	2005	59	77	65.3	87.8	65.1
	Röthlin et al[164]	1993
	Jiang et al[158]	2004
CA19-9 + CA 242 + CEA	Ni et al[142]	2005	29	96	NA	NA	NA

PPV: Positive predictive value; NPV: Negative predictive value; CA19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; CA 242: Carbohydrate antigen 242; NA: Not applicable.