Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium

Figure 1 Macroscopic views of milk-fed mice with colonic hemorrhage. Representative macroscopic views of newborn mice that were fed with glutamine-rich milk (GRM) (A), complete amino acid milk (CAM) (B), and glutamine-deleted milk (GDM) (C) are shown. Compared to the colons of GRM-mice and CAM-mice (asterisks), those of the GDM-mice appeared distended and edematous, with a pool of blood (arrow); D: Close-up views of the resected intestines from a CAM-mouse and a GDM-mouse, shown for comparison; E: Bar chart of the number of mice with melena on each day.