Non-alcoholic fatty liver disease: An early mediator predicting metabolic syndrome in obese children?

doi:10.3748/wjg.v17.i6.735

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Feb 14, 2011 (publication date) through Nov 30, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2011; 17(6): 735-742
Published online Feb 14, 2011. doi: 10.3748/wjg.v17.i6.735

Table 3 Clinical and laboratory data of non-alcoholic fatty liver disease compared with obese children without liver disorder

	Group 0 (n = 274)	NAFLD
		Group 1 (n = 436)	Group 2 (n = 151)
Age (yr)	10.36 ± 2.15	10.59 ± 1.85	10.40 ± 2.28
BMI (kg/m²)	26.58 ± 3.19	28.85 ± 3.69^a	28.78 ± 3.96^a
BMI Z-score	3.17 ± 1.26	3.33 ± 1.37	3.93 ± 1.60^a^c
Waist circumference (cm)	85.63 ± 10.17	91.58 ± 11.24^a	92.2 ± 9.31^a
Father BMI (kg/m²)	25.12 ± 3.68	25.68 ± 5.78	25.55 ± 3.75
Mother BMI (kg/m²)	22.83 ± 3.14	23.46 ± 3.61^a	23.64 ± 3.38^a
Systolic blood pressure (mmHg)	113.62 ± 11.89	118.30 ± 13.37^a	118.03 ± 12.73^a
Diastolic blood pressure (mmHg)	67.80 ± 9.02	69.00 ± 9.38	69.43 ± 8.67^a
ALT (U/L)	24 (8-74)	29 (4-75)^a	51.5 (76-561)^a^c
Uric acid (μmol/L)	352.9 (186.5-603.20)	365.9 (168.10-708.50)^a	412.5 (7.38-771.30)^a^c
Triglycerides (mmol/L)	1.4 (0.19-6.76)	1.42 (0.26-5.90)	1.77 (0.28-8.64)^a^c
Cholesterol (mmol/L)	4.37 ± 0.99	4.34 ± 0.87	4.71 ± 0.99^a^c
HDL	1.29 ± 0.39	1.23 ± 0.28	1.22 ± 0.28
LDL	2.52 ± 0.66	2.54 ± 0.68	2.68 ± 0.78
AI	2.07 ± 0.73	2.15 ± 0.70	2.31 ± 0.92^a
Fasting blood glucose (mmol/L)	4.82 ± 0.52	4.88 ± 0.69	4.95 ± 0.55^a
30-min OGTT glucose (mmol/L)	7.54 ± 1.17	7.73 ± 1.24	7.69 ± 1.21
120-min OGTT glucose (mmol/L)	5.66 ± 1.36	6.31 ± 1.42^a	6.22 ± 1.63^a
HbA1c (%)	5.70 ± 0.50	5.71 ± 0.53	5.65 ± 0.62
Fasting insulin (mIU/L)	12.7 (0.3-187.0)	17.0 (0.3-219.0)^a	18.2 (2.1-303.0)^a
30-min OGTT insulin (mIU/L)	85.3 (1.8-400.0)	112.0 (0.5-400.0)^a	106.2 (1.6-400.0)^a
120-min OGTT insulin (mIU/L)	36.3 (3.2-400.0)	63.6 (1.7-386.0)^a	69.8 (7.0-400.0)^a
HOMA-IR	2.61 (0.07-41.56)	3.71 (0.08-51.59)^a	3.95 (0.48-78.11)^a
WBISI	4.0 (0.6-16.4)	2.8 (0.9-24.2)^a	2.6 (0.4-16.7)^a

^aP < 0.05 vs group 0;

^cP < 0.05, group 1 vs group 2. Data are expressed as mean ± SD or median (range). NAFLD: Non-alcoholic fatty liver disease; BMI: Body mass index; ALT: Alanine aminotransferase; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; AI: Atherogenic index; OGTT: Oral glucose tolerance test; HOMA-IR: Homeostasis model assessment of insulin resistance; WBISI: Whole-body insulin sensitivity index.

Citation: Fu JF, Shi HB, Liu LR, Jiang P, Liang L, Wang CL, Liu XY. Non-alcoholic fatty liver disease: An early mediator predicting metabolic syndrome in obese children? World J Gastroenterol 2011; 17(6): 735-742
URL: https://www.wjgnet.com/1007-9327/full/v17/i6/735.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i6.735