Prediction of gastric cancer metastasis through urinary metabolomic investigation using GC/MS

Table 3 Metabolic differences in the two groups

Metabolites	Retention time	P value1	A (non-metastasis)	B (metastasis)	R2
Alanine	8.105	0.000	173.75 ± 39.59	19.28 ± 10.63	-0.89
Butanoic acid	9.412	0.000	32.09 ± 1.00	22.58 ± 0.72	-0.30
Glycerol	12.511	0.003	303.23 ± 26.16	235.04 ± 45.64	-0.22
Butanedioic acid	13.933	0.1 × 10-5	216.36 ± 2.63	319.43 ± 17.89	0.48
L-proline	20.497	0.000	184.99 ± 10.26	117.78 ± 7.05	-0.36
L-threonic acid	20.909	2.28 × 10-4	284.94 ± 46.47	181.48 ± 37.25	-0.36
Myo-inositol	29.032	0.000	33.08 ± 3.58	114.8 ± 2.20	2.47

¹P values were calculated based on Student t test (significance at P < 0.05);

²R value was calculated from the arithmetic mean values of each group. R = (B-A)/A. R with a positive value indicates a relatively higher concentration in metastasis group while a negative value means a relatively lower concentration as compared with the non-metastasis group.