Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

Table 6 Precore and core promoter mutations related to serum hepatitis B virus DNA and alanine aminotransferase in hepatitis B e antigen (+) patients

	Serum HBV DNA (log10 IU/mL) (mean ± SD) (n)		P-value	ALT (IU/L) [median (min-max)] (n)		P-value
	Absent	Present		Absent	Present
T1762/A17641	7.14 ± 1.46 (42)	5.60 ± 1.99 (29)	< 0.001	43.5 (13.0-748.0) (42)	48.5 (1.0-215.0) (29)	0.806
A18962	6.98 ± 1.27 (48)	-	-	47.0 (1.0-748.0) (48)	-	-
A18992	7.01 ± 1.25 (43)	6.68 ± 1.53 (5)	0.609	45.5 (1.0-748.0) (43)	55.0 (36.0-92.0) (5)	0.627
T1762/A1764 and A18962	6.98 ± 1.27 (48)	-	-	47.0 (1.0-748.0) (48)	-	-
T1762/A1764 or A18962	7.33 ± 1.23 (31)	6.33 ± 1.08 (17)	0.011	50.0 (15.0-748.0) (31)	41.5 (1.0-117.0) (17)	0.459

¹Total samples hepatitis B e antigen (HBeAg) (+) n = 71;

²Total samples HBeAg(+) n = 48. HBV: Hepatitis B virus; ALT: Alanine aminotransferase.