Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients

Table 1 Demographics and characteristics of patients enrolled in this study

Characteristics	Total	CH	LC	HCC	P-value
					CH vs LC	CH vs HCC	LC vs HCC
n (%)	179 (100.0)	64 (35.8)	65 (36.3)	50 (27.9)	-	-	-
Gender (male/female) (% male)	129/50 (72.1)	38/26 (59.4)	47/18 (72.3)	44/6 (88.0)	0.121	< 0.001	0.040
Age (yr, mean ± SD)	45.8 ± 12.3	39.7 ± 13.3	49.9 ± 10.8	48.4 ± 9.5	< 0.001	< 0.001	0.495
AFP [ng/mL, median (min-max)]	13.2 (0.1-3 295 000.0)	3.2 (0.1-5039.0)	11.8 (1.0-444 718.0)	704.8 (1.2-3 295 000.0)	< 0.001	< 0.001	< 0.001
AST [IU/L, median (min-max)]	66.0 (7.0-3618.0)	39.5 (7.0-481.0)	66.0 (15.0-297.0)	138.0 (9.0-3618.0)	< 0.001	< 0.001	< 0.001
ALT [IU/L, median (min-max)]	50.0 (1.0-860.0)	47 (6-748)	46 (9-216)	64 (1-860)	0.480	0.481	0.123
AST/ALT	1.28 (0.1-120.6)	0.9 (0.1-2.9)	1.4 (0.2-6.0)	2.1 (0.1-120.6)	< 0.001	< 0.001	< 0.001
Serum HBV DNA (log10 IU/mL, mean ± SD)	5.6 ± 2.0	6.1 ± 2.1	5.8 ± 1.4	4.6 ± 2.2	0.334	< 0.001	0.003
All HBeAg(+), (%)	71 (39.7)	36 (56.3)	19 (29.2)	16 (32.0)	0.002	0.010	0.749
All HBeAg(-), (%)	108 (60.3)	28 (43.8)	46 (70.8)	34 (68.0)
HBeAg(+); HBeAb(-), (%)	71 (39.7)	36 (56.3)	19 (29.2)	16 (32.0)	0.002	0.010	0.749
HBeAg(-); HBeAb(+), (%)	86 (48.0)	22 (34.4)	40 (61.5)	24 (48.0)	0.002	0.141	0.039
HBeAg(-); HBeAb(-), (%)	22 (12.3)	6 (9.4)	6 (9.2)	10 (20.0)	0.978	0.105	0.098
Genotype
B, n (%)	132 (73.7)	47 (73.4)	48 (73.8)	37 (74.0)	0.958	0.946	0.985
C, n (%)	47 (26.3)	17 (26.6)	17 (26.2)	13 (26.0)

CH: Chronic hepatitis; LC: Liver cirrhosis; HCC: Hepatocellular carcinoma; AFP: α-fetoprotein; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen; HBeAb: Hepatitis B e antibody.