Human papillomavirus in upper digestive tract tumors from three countries

Table 4 Physical status and E6 variants of human papillomavirus16 in Japan, Pakistan and Colombia

		n (%)
		All	Japan	Pakistan	Colombia	1P value
Oral cavity		39	7	27	5
Physical status	Episomal	2	0	2 (7)	0	0.147
	Mixed	3	0	1 (4)	2 (40)
	Integrated	34	7 (100)	24 (89)	3 (60)
HPV16 E6 variant	Prototype	6	3 (75)	3 (21)	0	0.048
	E-350G	13	1 (25)	9 (64)	3 (60)
	Asian	2	0	2 (14)	0
	Asian-American	2	0	0	2 (40)
Esophagus		24	9	9	6
Physical status	Episomal	2	0	0	2 (33)	0.017
	Mixed	5	0	4 (44)	1 (17)
	Integrated	17	9 (100)	5 (56)	3 (50)
HPV16 E6 variant	Prototype	2	2 (40)	0	0	< 0.001
	E-350G	8	3 (60)	5 (100)	0
	Asian	0	0	0	0
	Asian-American	6	0	0	6 (100)

¹P values were obtained by Fisher’s exact test. HPV: Human papillomavirus.