Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease

Table 1 Clinical characteristics and laboratory data of the study population (mean ± SD)

	Diagnosis
	H	FL	NASH	P value
Subjects (n)	21	43	41
Females	11	30	24	0.951
Age (yr)	19.1 ± 3.8	31.4 ± 13.9	35.6 ± 13	< 0.0012
Overweight	0	3	3	0.71
Obesity 1st grade	0	13	9	0.51
Obesity 2nd grade	0	9	6	0.61
Obesity 3rd grade	0	18	24	0.851
MS	0	24	36	0.0015
MUO	0	34	39	0.061
BMI
F	23.8 ± 1.13	38.8 ± 8.24	37.8 ± 6.6	< 0.0012
M	23.7 ± 0.6	38.6 ± 4.4	45.7 ± 10.5	0.013
WC (cm)
F	86.3 ± 1.4	114.8 ± 15.7	117.3 ± 17.7	0.0012
M	93.4 ± 2.3	121.2 ± 11.3	131.1 ± 15.1	< 0.0013
HOMA [median (range)]	1.77 (1.03-6)	2.3 (1.4-7.3)	4.1 (0.6-10.2)	< 0.00013
γ-GT U/L [median (range)]	33.1 (23.4-44.8)	40.5 (26-80)	54 (22.5-397)	< 0.00019
ALT U/L [median (range)]	27 (18-34)	36 (14-133)	40 (11-153)	0.0046
Uric acid	3.5 ± 0.4	5.1 ± 1.45	5.4 ± 1.4	< 0.0012
Ferritin
F	84.6 ± 10.3	139.6 ± 76.	149.2 ± 69	0.0012
M	166.8 ± 37.4	218.5 ± 121.	280 ± 103	0.014
Triglycerides	85 (66-121)	96 (51-290)	117 (51-386)	0.1610
HDL (mg/mL)
F	63.6 ± 7.97	51.8 ± 9.38	50 ± 11.15	0.0012
M	55.3 ± 8.4	50.8 ± 7.9	44 ± 4.4	< 0.0018
Triglycerides/HDL [median (range)]
F	1.32 (1.16-1.49)	2.19 (1.18-6.5)	1.51 (1.07-7.6)	0.0046
M	1.635 (1.39-1.75)	1.67 (1.25-2.7)	2.65 (1.25-8.8)	0.037

¹χ² test between fatty liver (FL) and non alcoholic steato hepatitis (NASH);

²analysis of variance (ANOVA) [significance between healthy (H) and FL and between H and NASH];

³ANOVA (significance between H and FL, between H and NASH and also between FL and NASH);

⁴ANOVA (significance between H and NASH);

⁵Pearson χ² (significance between FL and NASH);

⁶Kruskal-Wallis test (significance between H and FL and between H and NASH);

⁷Kruskal-Wallis test (significance between NASH and FL and between NASH and H);

⁸ANOVA (significance between NASH and FL and between NASH and H);

⁹Kruskal-Wallis test (significance between H and FL, between H and NASH and also between FL and NASH);

¹⁰Kruskal-Wallis test. F: Females; M: Males; n: Number; H: Healthy; FL: Fatty liver; NASH: Non alcoholic steato hepatitis; ALT: Alaninamino transferase; γ-GT: γ-glutamil transferase; HDL: High density lipoprotein; HOMA: Homeostatic metabolic assessment; BMI: Body mass index; MS: Metabolic syndrome; MUO: Metabolically unhealthy overweight/obese; WC: Waist circumference.