IκB kinase-beta inhibitor attenuates hepatic fibrosis in mice

Figure 5 IKK2 inhibitor decreased lipopolysaccharide-induced nuclear translocation of nuclear factor-κB p65 and P-IκBα in livers. Nuclear levels of the p65 subunit of nuclear factor-κB (NF-κB) were measured by Western blotting in different groups (A: Control; B: HF group; C: HF + LPS group; D: HF + LPS + IMD group). β-actin was used as a loading control. Administration of IMD at 30 mg/kg doses decreased the DNA binding activity of NF-κB, which was induced by HF and LPS in mice livers. HF: High-fat; LPS: Lipopolysaccharide; IMD: IKK2 inhibitor.