IκB kinase-beta inhibitor attenuates hepatic fibrosis in mice

Figure 1 IKK2 inhibitor prevented HF + LPS-induced liver injury, as determined by serum ALT and AST levels. The normal values for ALT and AST were 45 U/L and 160 U/L. Serum ALT (A) and AST (B) were measured in different groups (control group, HF group, LPS-induced HF group and IMD-treated group), data are expressed as mean ± SD. A: ^aP < 0.05 vs control group, ^cP < 0.05 vs the HF and LPS + HF groups; B: ^bP < 0.01 vs the control group, ^eP < 0.05 vs the LPS + HF group. HF: High-fat; LPS: Lipopolysaccharide; IMD: IKK2 inhibitor; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.