Serum leptin and ghrelin in chronic hepatitis C patients with steatosis

Table 5 Multiple logistic regression derived odds ratios and 95% confidence intervals for response to hepatitis C virus therapy among patients infected with hepatitis C virus genotype-1 with respect to hepatic steatosis, and leptin and ghrelin concentrations at baseline and at end of follow-up

Variable	Category or increment	ORs	95% CIs	P-value
At baseline
Hepatic steatosis	1 level more	0.12	0.02-0.66	0.01
Leptin	10 ng/mL more	0.43	0.22-0.83	0.01
Ghrelin	0.1 ng/mL more	1.11	0.67-2.01	0.63
HOMA-IR	1 level more	1.34	0.42-4.31	0.63
Alternatively introduced variables
Fibrosis	1 level more	0.36	0.13 -0.96	0.04
Leptin	10 ng/mL more	0.45	0.24-0.86	0.02
Ghrelin	0.1 ng/mL more	1.35	0.82-2.45	0.26
HOMA-IR	1 level more	0.96	0.33-2.79	0.94
At end of follow-up
Hepatic steatosis	1 level more	0.13	0.02-0.89	0.04
Leptin	10 ng/mL more	0.38	0.18-0.81	0.01
Ghrelin	0.1 ng/mL more	1.22	0.74-2.01	0.41
HOMA-IR	1 level more	1.98	0.54-7.30	0.30
Alternatively introduced variables
Fibrosis	1 level more	0.30	0.10-0.93	0.04
Leptin	10 ng/mL more	0.34	0.16-0.72	0.01
Ghrelin	0.1 ng/mL more	1.22	0.74-1.82	0.47
HOMA-IR	1 level more	1.28	0.43-3.79	0.66

CI: Confidence interval; HOMA-IR: Homeostasis model assessment insulin resistance; ORs: Odds ratios.