Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model

Figure 2 Erlotinib treatment did not worsen inflammation. A: Effect of erlotinib treatment on weight change in an animal model of colitis-associated dysplasia (n = 10-20 per group ± SE); B: Weight change following initial reactivation of colitis; C: Effect of erlotinib treatment on macroscopic damage score in an animal model of colitis-associated dysplasia. The average macroscopic score (including the presence of adhesions, thickness of the tissue, presence or absence of diarrhea, and grade of ulceration) was significantly higher in all trinitrobenzene sulfonic acid-treated animals whether treated with vehicle or drug (^aP < 0.05 vs normal animals, n = 12-20 ± SE).