Effects of CpG-ODNs on phenotype and function of monocyte-derived dendritic cells in chronic hepatitis B

doi:10.3748/wjg.v17.i43.4825

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2011; 17(43): 4825-4830
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4825

Table 1 Effects of different immunologic adjuvants on expression levels of surface molecules (%) on DCs derived from blood monocytes of patients with chronic hepatitis B

Surface molecules	CpG	CpG + HBsAg	TNF-α	HBsAg	PBS
HLA-DR	93.8 ± 3.7^a	95.1 ± 4.5^a	94.8 ± 3.1	87.6 ± 4.3^a	70.4 ± 3.9
CD86	83.7 ± 5.3	81.5 ± 3.2	82.3 ± 2.7	83.2 ± 3.6	80.2 ± 4.2
CD1a	12.0 ± 0.9	44.5 ± 1.2^a	12.7 ± 1.9	15.0 ± 2.5	13.6 ± 0.8

DCs: Dendritic cells; CHB: Chronic hepatitis B; CpG-ODNs: Synthetic nonmethylated CpG-containing oligodeoxynucleotide; HBsAg: Hepatitis B surface antigen; PBS: Phosphate buffer solution; TNF: Tumor necrosis factor. HLA-DR, CD86 and CD1a are the specific surface molecules of DCs; CpG, CpG + HBsAg, TNF-α and HBsAg are the different adjuvants on DCs.

^aP ＜ 0.05 using Student’s t test, represents the stimulating effects of different immunologic adjuvants in comparison to control group (PBS).

Citation: Xiang XX, Zhou XQ, Wang JX, Xie Q, Cai X, Yu H, Zhou HJ. Effects of CpG-ODNs on phenotype and function of monocyte-derived dendritic cells in chronic hepatitis B. World J Gastroenterol 2011; 17(43): 4825-4830
URL: https://www.wjgnet.com/1007-9327/full/v17/i43/4825.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i43.4825