De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients

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Nov 21, 2011 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 21, 2011; 17(43): 4804-4809
Published online Nov 21, 2011. doi: 10.3748/wjg.v17.i43.4804

Table 2 Biochemical responses of the patients, median (min-max)

	De novo combination group (n = 10)					Add-on combination group (n = 20)
	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk aftercombinationtreatment	48 wk after combination treatment	2 wk before combination treatment	4 wk after combination treatment	12 wk after combination treatment	24 wk after combination treatment	48 wk after combination treatment
Child-Pugh score	11 (9-13)	10 (8-12)	10 (8-12)	9 (7-11)^c	7 (6-9)^c^a	11 (9-13)	10 (9-12)	10 (9-12)	10 (7-11)^c	9 (7-10)^c
Serum ALT (IU/L)	124 (82-156)^a	111 (80-141)^a	109 (69-125)^a	89 (59-112)^c^a	49 (28-67)^c^a	283 (187-321)	251 (171-302)^c	218 (146-277)^c	173 (105-239)^c	105 (65-186)^c
Serum TBIL (μmol/L)	49.5 (23-72)^a	47.3 (25.0-70.1)^a	41.3 (25.5-63.0)^a	37.8 (22.5-57.4)^c^a	31.0 (22.0-41.0)^c^a	73.5 (49.0-99.6)	68.3 (44.5-88.7)	63.5 (35.8-79.0)^c	56.7 (32.0-72.3)^c	41.2(29.0-58.1)^c
Serum ALB (g/L)	29.75(25.40-34.00)^a	30.15(27.20-34.10)^a	30.55(27.60-33.00)^a	32.80(29.00-35.00)^c^a	34.00(30.00-37.00)^c^a	26.65(23.00-32.00)	28.20(25.60-32.90)	27.85(25.00-31.90)	28.75(25.50-33.00)^c	30.5(28.0-34.8)^c

^aP < 0.05 vs add-on combination group;

^cP < 0.05 vs 2 wk before combination treatment in the same group. ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALB: Albumin.

Citation: Fan XH, Geng JZ, Wang LF, Zheng YY, Lu HY, Li J, Xu XY. De novo combination therapy with lamivudine and adefovir dipivoxil in chronic hepatitis B patients. World J Gastroenterol 2011; 17(43): 4804-4809
URL: https://www.wjgnet.com/1007-9327/full/v17/i43/4804.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i43.4804