Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

Table 4 Among Helicobacter pylori positive persons (according to the gold standard, n = 149), the relationship between antibodies to Helicobacter pylori immunoglobulin G optical density and delta over baseline for the ¹³C urea breath test and demographics, histology and endoscopy outcomes

Factors	Anti-HP IgG OD1			13C-UBT DOB2
	High, OD≥1.1, (n = 76)	Low, OD < 1.1, (n = 73)	P value	High,≥10%, (n = 71)	Low, < 10%, (n = 78)	P value
Demographics
% Male	54% (41)	19% (14)	< 0.0001	31% (22)	42% (33)	0.15
% ≥ 50 years of age	33% (25)	40% (29)	0.39	53% (27)	29% (27)	0.002
Factors from histological examination
% Intestinal metaplasia	11% (8)	12% (9)	0.73	8% (6)	14% (11)	0.27
% Acute gastritis	55% (42)	49% (36)	0.47	49% (35)	55% (43)	0.48
% Chronic gastritis	93% (71)	77% (56)	0.003	86% (61)	85% (66)	0.82
% Numerous H. pylori	42% (32)	36% (26)	0.42	54% (38)	26% (20)	0.0005
Endoscopic factors
% Ulcer	10% (7)	11% (8)	0.76	9% (6)	12% (9)	0.57
% Gastritis	58% (42)	40% (29)	0.03	49% (34)	48% (37)	0.88

¹Antibodies to Helicobacter pylori (H. pylori) immunoglobulin G optical density (anti-HP IgG OD) was associated with male gender [P < 0.0001, odds ratio (OR) = 6.2] and chronic gastritis (P = 0.003, OR = 5.8) on multivariate analysis.

²Delta over baseline (DOB) from ¹³C urea breath test (UBT) test was associated with numerous H. pylori (P = 0.0005, OR = 3.6) and older age (P = 0.01, OR = 2.5) on multivariate analysis.