Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population

doi:10.3748/wjg.v17.i42.4682

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Nov 14, 2011; 17(42): 4682-4688
Published online Nov 14, 2011. doi: 10.3748/wjg.v17.i42.4682

Table 3 Sensitivity and specificity of non-invasive tests in relation to invasive tests and a gold standard in 280 patients from Anchorage, Alaska, 1999-2000¹

Test type 1	Test type 2	Sensitivity	Specificity	NPV²	PPV²	Accuracy
¹³C-UBT³vs	Histology	93.6% (131/140)	82.9% (116/140)	92.8% (116/125)	84.5% (131/155)	88.2% (247/280)
	Histology and CLO test^{^®4}	96.8% (121/125)	78.1% (121/155)	96.8% (121/125)	78.1% (121/155)	86.4% (242/280)
	Culture	93.1% (134/144)	84.6% (115/136)	92.0% (115/125)	86.5% (134/155)	89.0% (249/280)
	Culture and CLO test^®	94.6% (123/130)	78.7% (118/150)	94.4% (118/125)	79.4% (123/155)	86.1% (241/280)
	Gold standard	93.3% (139/149)	87.8% (115/131)	92.0% (115/125)	89.7% (139/155)	90.7% (254/280)
Anti-HP IgG vs	Histology	91.5% (118/129)	61.8% (81/131)	88.0% (81/92)	70.2% (118/168)	76.5% (199/260)
	Histology and CLO test^®	93.1% (108/116)	58.3% (84/144)	91.3% (84/92)	64.3% (108/168)	73.8% (192/260)
	Culture	93.3% (126/135)	66.4% (83/125)	90.2% (83/92)	75.0% (126/168)	80.3% (209/260)
	Culture and CLO test^®	93.4% (113/121)	60.4% (84/139)	91.3% (84/92)	67.3% (113/168)	75.8% (197/260)
	Gold standard	92.9% (130/140)	68.3% (82/120)	89.1% (82/92)	77.4% (130/168)	81.5% (212/260)
Anti-HP IgG vs	¹³C-UBT	91.0% (131/144)	68.1% (79/116)	85.9% (79//92)	78.0% (131/168)	80.8% (210/260)
Histology vs	Culture	87.5% (126/144)	89.7% (122/136)	87.1% (122/140)	90.0% (126/140)	88.6% (248/280)
CLO test^®vs	Histology	89.3% (125/140)	90.7% (127/140)	89.4% (127/142)	90.6% (125/138)	90.1% (252/280)
CLO test^®vs	Culture	90.3% (130/144)	94.1% (128/136)	90.1% (128/142)	94.2% (130/138)	92.1% (258/280)

¹The gold standard was a positive Helicobacter pylori (H. pylori) test by culture or, in the case of a negative culture result, a positive histology result and a positive campylobacter-like organism (CLO) test.

²Negative and positive predictive value (NPV and PPV).

¹³C urea breath test (UBT)³, BreathTek^TM, Meretek Diagnostics Inc. ⁴Rapid urease test, Ballard Medical Products. Anti-HP IgG: Antibodies to H. pylori immunoglobulin G.

Citation: Bruden DL, Bruce MG, Miernyk KM, Morris J, Hurlburt D, Hennessy TW, Peters H, Sacco F, Parkinson AJ, McMahon BJ. Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population. World J Gastroenterol 2011; 17(42): 4682-4688
URL: https://www.wjgnet.com/1007-9327/full/v17/i42/4682.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i42.4682