Systematic review of health-related quality of life after esophagectomy for esophageal cancer

Table 1 Studies characteristics: Aims of the studies and timing of health-related quality of life recording

Sudy	Study aim	Timing post op HRQL measures
McLarty et al[54]	Analysis of HRQL in long term survivors after surgery alone	A single assessment > 60 mo
De Boer et al[53]	Analysis of HRQL in long term survivors after transhiatal esophagectomy	A single assessment 3.5 (2.1-5.4) yr
Headrick et al[49]	Analysis of HRQL in long term survivors after esophagectomy for HGD or adenocarcinoma	A single assessment 5.3 (0.5-9) yr
Cense et al[52]	Analysis of HRQL in long term survivors after esophagocolonplasty	A single assessment 35 (7-97) mo
Moraca et al[50]	Analysis of HRQL in long term survivors after esophagectomy for HGD or Tis	A single assessment 4.9 (0.5-12) yr
Reynolds et al[55]	Comparison between HRQL after neoadjuvant CT-RT+ surgery and after surgery alone	Baseline, after CT-RT, 3, 6, 9, 12 mo po
Avery et al[56]	Comparison between HRQL after neoadjuvant CT-RT+ surgery and after definitive CT-RT	1, 5, 3, 6, 9 mo
van Meerten et al[57]	Analysis of HRQL after neoadjuvant CT-RT + surgery	Baseline, after CT-RT, 3, 6, 9, 12 mo po
Wang et al[59]	Comparison between open surgery and minimally invasive esophagectomy	2, 4, 12, 24 wk
Parameswaran et al[58]	Analysis of HRQL after minimally invasive esophagectomy	6, 12 mo
Viklund et al[45]	Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction)	A single assessment 6 mo
Rutegard et al[46]	Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction)	A single assessment 6 mo
Rutegard et al[47]	Analysis of HRQL predictors after esophagectomy for cancer (type of recstruction)	A single assessment 6 mo
Olsen et al[60]	Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery)	A single assessmentat 24 mo po
Lagergren et al[61]	Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery)	Baseline and 36 mo
Djarv et al[62]	Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery)	6, 36 mo
Courrech Staal et al[63]	Analysis of HRQL in long term survivors (surgery alone or neoadjuvant CT-RT + surgery)	A single assessment at 54 (16–162) mo
Blazeby et al[64]	Comparison between HRQL after surgery alone and after palliative RT	A single assessment 16 (10-24) wk
Ariga et al[65]	Comparison between surgery alone and definitive CT-RT + salvage surgery	A single assessment 24 mo
Schneider et al[48]	Comparison between HRQL after emergency and elective esophagectomy	1 wk and 9 mo
Rosmolen et al[51]	Comparison between HRQL after endoscopical ablation and esophagectomy for early Barrett’s neoplasms	A single assessment at 24 (17–35) mo

The 21 studies included in the analysis are listed according their aim and then chronologically. HRQL: Health-related quality of life; HGD: High grade dysplasia; CT-RT: Chemotherapy-radiotherapy; op: Operative; po: Post-operative.