Review
Copyright ©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Nov 7, 2011; 17(41): 4554-4562
Published online Nov 7, 2011. doi: 10.3748/wjg.v17.i41.4554
Table 3 Literature on argon plasma coagulation therapy use in chronic radiation proctopathy
Study Ref.nMean age (yr) (range)Settings -flow rate- powerMean No. of sessions per patientResponserateImprovement in anemia (% patients), mean increase in Hgb (gm%)Relief of transfusion dependencyFollow-up duration mean (mo)Complications/Side effects% requiring transfusion
Swan et al[49], 20105072.1 (51-87)1.4-2 L/min, 50 W1.36 (1-3)96%1.9 gm% mean increase20.6 (6-48)Short-term: 17 (34%) patients (proctalgia in 13, rectal mucous discharge in 4, incontinence in 1, fever in 1, and bleeding in 1); long-term: 1 (2%) asymptomatic rectal stricture
Karamanolis et al[46], 20095668.4 (45–86)2.0 L/min, 40W2 (1-8)Mild (100%), severe (79%), total (89%)N/A7/917.9 (6-33)one case of colonic explosion without perforation; No strictures or persistent ulcers; 2 on anticoagulation with recurrence9/56 (16%)
Tormo et al[74], 20092274.32 L/min, 50 W2.58 (1-7), median-2100%N/AN/AN/ANone2/22 (9%)
Alfadhli et al[14], 20081474.71.2-2 L/min, 45-50 W1.7878.5%2 gm% mean increaseN/A32/14 (33.3%) mildN/A
Latorre et al[75], 20083870.93.6 ± 2.7mean2.7 gm% mean increase28
Dees et al[76],2006482 L/min, 50 WMedian-398%Two patients-recurrent blood loss on anticoagulation; 1-ulcer6/48 (12.5%)
Ben-Soussan et al[53], 20042773.1 (53-86)0.8-1.0 L/min, 40-50 W2.66 (1-7)92%13.6 (3-31)Side effects-anal/rectal pain (n = 3), vagal symptoms (n = 2), 3 colonic explosions-1 with perforation requiring surgery, no stricture8/27 (30%)
Higuera et al[77], 2004101.5-2.0 L/min, 60 W1.9 (1-4), median (2)100%1.5-1.9 gm% mean increase1/1 (100%)31.1 (10-45)No ulcers/strictures, 1 (10%)-tenesmus
Sebastian et al[39], 20042569 (53–77)1.5 L/min, 30 W (25-40 W)median-121/25 (76%, 81% or 84%??)2.4 gm% mean increaseMedian 14-1-rectal pain
Urban et al[78], 200481-4100%
Ravizza et al[51], 20032772 (62-83)3 L/min + 60 W (n = 17) reduced to 2 L/min and 40 W (n = 10)2 (1-5)85% marked improvement, 10/27 only had minor bleeding, 48% Complete resolution3.2 g/dL mean increase6/6 (100%) transfusion relief11.5 (1-24)Short term-2/27 (7%), 1-transient anal/rectal pain, 1-fever; long-14/27 (52%)-asymptomatic rectal ulcers6/27
Gheorghe et al[58], 20034260 W (23), 50 W (19)1.34, 1.9
Canard et al[48], 20033070.7 (58-85)0.8-2 L/min, 30-80 W2.3 (1-5)(87%)20 (3-35)Overall-47%; 3 severe (10%): 1 severe bleeding, 1 extensive necrosis of lower part of rectum, 1 perforation. 3 microrectitis and 2 asymptomatic rectal stenosis. Post-Rx pain in 6 patients (20%)17%
Venkatesh et al[79], 20024064-831-1.5 L/min, 40-60 WMean-1.35 median-1 (1-2)97.5%- 97.5% patients20/21 (95.2%)NR 3-301-urinary retention, 2-fever requiring antibiotics21/40 (52.5%)
Taieb et al[80], 20011173 (54-86)0.8-2 L/min, 50W3.2 (1-5)82% CR, 18% PR3.8 gm% mean increase7/7 (100%)19 (7-30)7/11 (63.6%)
Tjandra et al[41], 2001121.5L/min, 40 W2 (1-3)50% CR, 50% PR, 83% Signi1.1 gm% mean increase4/4 (100%)11 (4-17)None4/12 (33%)
Smith et al[81], 200171.6 L/min, 40-45 W1-371% CR, 29% PR4-13None
Rolachon et al[82], 20001270.31.0 L/min, 50 WMean (2.8 ± 0.8)66% CR, 83% PR1.8 gm% mean increase63/12 (25%), 2-chronic rectal ulcerations, 1-asymptomatic rectal stenosis
Kaassis et al[44], 20001673.5 (62-80)0.6 L/min, 40 WMean-3.7 (2-8)44% CR, 56% PR3/3 (100%)10.7 (8-28)No3/16 (18.75%)
Tam et al[40], 2000152 L/min, 60 WMedian-2 (1-4)100%2.5 gm% mean increase3/3 (100%)Median-24 (8-35)2-asymptomatic rectal strictures requiring dilation3/15 (20%)
Silva et al[45], 19992865 (42-77)1.5 L/min, 50 W2.9 (1-8)93%1.2 gm% mean increase-10 (1-15)No, 3-transient anal pain15/28 (53%)
Fantin et al[62], 199973 L/min, 60 W2 (2-4)100%Median 24 (18-24)No
Chutkan et al[83], 199712192%6.6No3/12 (25%)
Villavicencio et al[50], 200221Median 72.6 ( 58-86)1.2-2.0 L/min, 45-50 W1.7 median (1-4)95%100% patients4/4 (100%)10.5 Median (1-29)4-rectal pain, tenesmus, diarrhea4/21 (19%)
Rotondano et al[84], 2003240.8-1.2 L/min, 40 WMedian 2.5100%1-RV Fistula
Zinicola et al[42], 2003142 L/min, 65 W2 (1-4)86%%3/3 (100%)19 (5-41)1-asymptomatic recto-sigmoid stenosis3/14 (21%)