Fascin promotes the motility and invasiveness of pancreatic cancer cells

Figure 5 The effect of fascin overexpression on invasiveness of MIA PaCa-2 cells. A: Matrigel invasion assay showed that the overexpression of fascin dramatically increased cell invasive properties compared with control cells. (^aP < 0.05); B: In vivo invasion assay. Tumors from fascin-overexpressing MIA PaCa-2 Fascin cells showed an increase in skin invasion when compared with control MIA PaCa-2 Vector cells; C: Histological examination of skin invasion of tumors from MIA PaCa-2 Fascin cells and control MIA PaCa-2 cells. (a) Tumor from MIA PaCa-2 Fascin cells had skin invasion and (b) tumor from MIA PaCa-2 Vector cells showed no skin invasion (HE, × 150). HE: Hematoxylin and eosin.