Fascin promotes the motility and invasiveness of pancreatic cancer cells

Figure 4 Fascin promotes cell migration and inhibits cell aggregation. A: The effect of fascin overexpression on the cell migration of MIA PaCa-2 cells. Images were taken at 0 h (a, c) and 20 h (b, d) (× 60). MIA PaCa-2 Fascin cells (a, b) repopulated the open space more efficiently than did MIA PaCa-2 Vector cells (c, d). The arrows in figure 4a (MIA PaCa-2-Fascin cells group) and figure 4c (MIA PaCa-2-Vector cells group) showed initial distances between two side of cells (0 h), and the arrow in figure 4b (MIA PaCa-2-Fascin cells group) was short than the one in figure 4d (MIA PaCa-2-Vector cells group) in 20 h, which showed the ability of cell migration increased in the state of fascin overexpression; B: The effect of fascin overexpression on the aggregation of MIA PaCa-2 cells. Images were taken at 12 h (× 60). The heterogeneous expression of fascin resulted in a reduction in aggregation compared with control cells. a: MIA PaCa-2 Fascin cells; b: MIA PaCa-2 Vector cells.