Helicobacter pylori infection in bleeding peptic ulcer patients after non-steroidal antiinflammatory drug consumption

Table 2 Demographic, clinical and endoscopic characteristics of all patients with bleeding from peptic ulcers after consumption of nonsteroidal anti-inflammatory drugs, grouped according to whether they did or did not have Helicobacter pylori infection n (%)

	Patients(n = 80)	Helicobacter pylori negative(n = 36)	Helicobacter pylori positive(n = 44)	P-value
Males	61 (76.3)	28 (77.8)	33 (75.0)	0.771
Age (yr) (mean ± SD)	61.2 ± 15.9	60.6 ± 18.3	61.7 ± 13.9	0.767
Smoker				0.703
Non-smoker	43 (53.8)	21 (58.3)	22 (50.0)
Current	26 (32.5)	10 (27.8)	16 (36.4)
Ex-smoker	11 (13.8)	5 (13.9)	6 (13.6)
Symptoms on presentation				0.721
Hematemesis	11 (13.8)	4 (11.1)	7 (15.9)
Melena	58 (72.5)	26 (72.2)	32 (72.7)
Hematemesis and melena	11 (13.8)	6 (16.7)	5 (11.4)
Initial mean hemoglobin (g/dL)	9.2 ± 2.3	8.7 ± 2.2	9.6 ± 2.4	0.076
American Society of Anesthesiology class				0.600
1-2	62 (77.5)	26 (72.2)	36 (81.8)
3	15 (18.8)	8 (22.2)	7 (15.9)
4	3 (3.8)	2 (5.6)	1 (2.3)
Complete Rockall score				0.183
0-2	39 (48.8)	19 (52.8)	20 (45.5)
3-5	34 (42.5)	12 (33.3)	22 (50)
6-8	7 (8.8)	5 (13.9)	2 (4.5)
1Comorbidity	27 (33.8)	12 (33.3)	15 (34.1)	0.943
Occasional consumption of NSAIDs	47 (58.8)	19 (52.8)	28 (63.6)	0.326
Patients on chronic LD ASA	33 (41.3)	17 (47.2)	16 (36.4)	0.326
Other antiplatelet drugs	5 (6.3)	2 (5.6)	3 (6.8)	0.999
Anticoagulants	2 (2.5)	2 (5.6)	0 (0)	0.199
Other drugs	39 (48.8)	15 (41.7)	24 (54.5)	0.252
Locations of ulcers				0.515
Duodenum alone	41 (51.3)	21 (58.3)	20 (45.5)
Stomach alone	29 (36.3)	11 (30.6)	18 (40.9)
Stomach and duodenum	10 (12.5)	4 (11.1)	6 (13.6)
Forrest				0.684
1a	2 (2.5)	1 (2.8)	1 (2.3)
1b	12 (15.0)	6 (16.7)	6 (13.6)
2a	4 (5.0)	1 (2.8)	3 (6.8)
2b	3 (3.8)	1 (2.8)	2 (4.6)
2c	16 (20.0)	10 (27.8)	6 (13.6)
3	43 (53.8)	17 (47.2)	26 (59.1)

NSAID: Nonsteroidal anti-inflammatory drug; LD ASA; Low dose aspirin.

¹According to the Charlson Comorbidity Index. Because of rounding, not all percentages total 100.