Nestin in gastrointestinal and other cancers: Effects on cells and tumor angiogenesis

Figure 1 Tumor stem cells and nestin. Tumor stem cells have specific characteristics, including multi-lineage potential, self-renewal potential, refractoriness to therapy, and high invasiveness and metastatic potential. The origin of tumor stem cells has not been well clarified, but it is known that some tumor stem cells express nestin in their cytoplasm. Nestin in tumor stem cells thus is considered to be a novel therapeutic target.