Intracranial hemorrhage in patients treated with bevacizumab: Report of two cases

Table 1 Summary of 8 cases of bevacizumab-associated central nervous system bleeding

Study	Yr	Age	Gender	Primary location	Bevacizumab dose (mg/kg)	Bleeding site	Combination drug	Comorbidity	Survival status1
Chen et al[15]	2006	NR	NR	Colorectum	5	NR	FU, LV	NR	NR
Nguyen et al[13]	2007	72	Female	Fallopian tube	NR	Pontine	GEM	Upper extremity	NR
								Venous thrombosis
		59	Female	Peritoneum	NR	Subarachnoid	IRI, CDDP	Pulmonary emboli	NR
Giantonio et al[16]	2007	NR	NR	Colorectum	10	NR	None or FOLFOX	NR	Dead
		NR	NR	Colorectum	10	NR	None or FOLFOX	NR	Dead
Tanvetyanon et al[14]	2009	52	Male	Lung	15	Large vein draining to the superior sagittal sinus	PTX, CBDCA	AVM	Dead
Our cases	2011	64	Male	Rectum	5	Right frontal lobe, right temporal lobe,	FOLFOX	Hypertension	Alive
						Left occipital lobe, right parietal lobe
		65	Male	Colon	5	right thalamus	FOLFIRI	Hypertension	Alive

¹At time of publication. 5-FU: 5-fluorouracil; LV: Leucovorin; GEM: Gemcitabine; IRI: Irinotecan; CDDP: Cisplatin; CBDCA: Carboplatin; PTX: Paclitaxel; FOLFOX: Oxaliplatin/5-FU/LV; FOLFIRI: IRI/5-FU/LV; AVM: Arteriovenous malformation; NR: Not reported.