Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model

Figure 2 Histological changes of methionine choline-deficient diet-fed rat liver (hematoxylin eosin x 200). Extremely large vesicle fat deposits in almost the entire lobules were detected even as early as two weeks after the start of the methionine choline-deficient diet. By 8 wk, spotty necrosis was dispersed and by 16 wk, there was fibrosis extending from the central vein. A: Control; B: Two weeks methionine choline-deficient (MCD); C: Four weeks MCD; D: Eight weeks MCD; E: Twelve weeks MCD; F: Sixteen weeks MCD.