Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver

doi:10.3748/wjg.v17.i37.4184

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Oct 7, 2011 (publication date) through Oct 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2011; 17(37): 4184-4190
Published online Oct 7, 2011. doi: 10.3748/wjg.v17.i37.4184

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Figure 2 Heme oxygenase-1 protein expression pattern in liver sections from lean and obese Zucker rats after treatment with pentobarbital or isoflurane. A: Heme oxygenase-1 (HO-1) protein was restricted to spindle-shaped sinusoidal lining cells in pentobarbital treated animals; B: Isoflurane (ISO) administration led to markedly upregulated HO-1 protein expression in hepatocytes of the perivenular area; C and D: No detectable induction of HO-1 protein in hepatocytes of obese animals was detected after ISO treatment. PEN: Pentobarbital; ISO: Isoflurane; LEAN: Lean Zucker rats; FAT: Obese Zucker rats.

Citation: Stoll P, Schwer CI, Goebel U, Buerkle H, Hoetzel A, Schmidt R. Hepatic steatosis prevents heme oxygenase-1 induction by isoflurane in the rat liver. World J Gastroenterol 2011; 17(37): 4184-4190
URL: https://www.wjgnet.com/1007-9327/full/v17/i37/4184.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i37.4184