Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Figure 11 The expression of mRNA for cyclooxygenase-2, IL-1β, tumor necrosis factor-α and inducible form of nitric oxide synthase in colonic mucosa of intact rats (lane 1) those treated with vehicle (lane 2), aspirin (lane 3) and nitric oxide-aspirin (lane 4) at day 10 after induction of colitis. Mean ± SE of 4 determinations in 4 rats. ^aP < 0.05 vs intact colonic mucosa; ^cP < 0.05 vs rats with trinitrobenzenesulfonic acid colitis administered with vehicle (Veh); ^eP < 0.05 vs vehicle and aspirin (ASA) groups. COX: Cyclooxygenase; TNF: Tumor necrosis factor; iNOS: Inducible form of nitric oxide synthase; M: Marker.