Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Figure 10 The area of colonic damage and changes in colonic blood flow on day 10 after colitis induction in rats with intact sensory nerves and in those with capsaicin-sensory denervation treated with vehicle (saline) or nitric oxide-aspirin (80 mg/kg per day ig) with or without administration of calcitonin gene related peptide (10 μg/kg per day sc). Mean ± SE of 6-8 rats. ^aP < 0.05 vs vehicle (control); ^cP < 0.05 vs trinitrobenzenesulfonic acid (TNBS) rats without capsaicin denervation; ^eP < 0.02 vs rats with TNBS colitis treated with nitric oxide-aspirin (NO-ASA). CGRP: Calcitonin gene related peptide; CBF: Colonic blood flow.