Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis

Figure 2 The effect of 10 d administration of nitric oxide-aspirin, applied ig in gradual concentrations ranging from 20 mg/kg up to 120 mg/kg on the area of colonic lesions, alterations in colonic blood flow and plasma NOx concentrations in rats with trinitrobenzenesulfonic acid-induced colitis on day 10. Mean ± SE of 6-8 rats. ^aP < 0.05 vs vehicle (control) and animals treated with a dose of 20 mg/kg nitric oxide-aspirin (NO-ASA). TNBS: Trinitrobenzenesulfonic acid; CBF: Colonic blood flow.