MicroRNAs as a potential prognostic factor in gastric cancer

doi:10.3748/wjg.v17.i35.3976

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Sep 21, 2011 (publication date) through Dec 1, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 21, 2011; 17(35): 3976-3985
Published online Sep 21, 2011. doi: 10.3748/wjg.v17.i35.3976

Table 2 Differential expression of microRNAs by prognostic groups

miR	P value	Fold change	Median value
			Good prognosis	Bad prognosis
miR-451	0.0002 (0.0046)	2.66 (3.14)	260 (18.9)	690 (20.6)
miR-195	0.0046 (0.017)	2.17 (3.29)	270 (17.6)	580 (19.4)
miR-199a-3p	0.0027 (0.045)	2.15 (1.97)	1100 (20.1)	2300 (21.1)

Comparison between patients with recurrence of gastric cancer within three years from surgery (bad prognosis) and patients without a recurrence (good prognosis). P values were calculated by a Wilcoxon-Mann-Whitney rank-sum test. Only miRs that passed the false discovery rate = 0.1 threshold (P < 0.0235) and had a fold-change greater than 2 (in the microarray data) are listed. Values in parenthesis show the same statistics for the quantitative real-time polymerase chain reaction verification set. Cycle threshold (C_T) values are the inverses of the log signals; therefore, median values are given in 50-C_T to maintain the same sense as the array data.

Citation: Brenner B, Hoshen MB, Purim O, David MB, Ashkenazi K, Marshak G, Kundel Y, Brenner R, Morgenstern S, Halpern M, Rosenfeld N, Chajut A, Niv Y, Kushnir M. MicroRNAs as a potential prognostic factor in gastric cancer. World J Gastroenterol 2011; 17(35): 3976-3985
URL: https://www.wjgnet.com/1007-9327/full/v17/i35/3976.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i35.3976