Distribution, function and physiological role of melatonin in the lower gut

Table 3 Case reports of melatonin self administration in patients with ulcerative colitis and Crohn’s disease

Authors	Age, gender,disease	Treatment	Dose	Result
Maldonado et al[113]	56, male, UC	Added melatonin to the otherwise unchanged drug treatment (salazosulfapyridine, corticosteroids)	3 mg/od	Two months later, the patient started to experience the symptoms of active UC, including bloody diarrhea
Jan et al[111] Mann[112]	47, male, UC	Added melatonin to an existing medication of mesalamine due to ongoing bloody diarrhea	3 mg/od	Symptoms resolved fast (2–3 d) and the beneficial effect was long lasting
Calvo et al[114]	35, female, CD	After becoming pregnant, the patient interrupted the treatment with melatonin, corticoids and salazosulfapyridine and symptoms of CD emerged again	3 mg/od	Recurrence of diarrhea and abdominal cramps within 4 d

od: Once daily; UC: Ulcerative colitis; CD: Crohn’s disease.