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World J Gastroenterol. Sep 7, 2011; 17(33): 3776-3784
Published online Sep 7, 2011. doi: 10.3748/wjg.v17.i33.3776
Published online Sep 7, 2011. doi: 10.3748/wjg.v17.i33.3776
Red pulp |
Extramedullary hematopoiesis if required |
Facilitating an environment wherein erythrocytes rid themselves of solid waste material |
Blood filter for foreign material and damaged and senescent blood cells |
Storage site for iron, erythrocytes, platelets, plasmablasts and plasma cells |
Rapid release of antigen-specific antibodies into the circulation produced by red pulp plasma cells |
Defense against bacteria using iron metabolism by its macrophages |
White pulp |
T cell zone (periarterial lymphatic sheath) and B cell zone (follicles) |
Storage site for B and T lymphocytes |
Development of B and T lymphocytes upon antigenic challenge |
Release of immunoglobulins upon antigenic challenge by B lymphocytes |
Production of immune mediators involved in clearance of bacteria such as complement, opsonins, properdin and tuftsin |
Marginal zone |
Phagocytosis of circulating microorganisms and immune complexes by MZ macrophages |
Development of marginal zone B lymphocytes upon TI-2 antigenic challenge |
Blood trafficking of B and T lymphocytes |
Release of immunoglobulins upon antigenic challenge by splenic B lymphocytes |
- Citation: Tarantino G, Savastano S, Capone D, Colao A. Spleen: A new role for an old player? World J Gastroenterol 2011; 17(33): 3776-3784
- URL: https://www.wjgnet.com/1007-9327/full/v17/i33/3776.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i33.3776