Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma

Table 2 Statistical analysis of Toll-like receptor expression and clinicopathologic factors in esophageal carcinoma

Characteristics	TLR3	P	TLR4	P	TLR7	P	TLR9	P
	Positive (%)		Positive (%)		Positive (%)		Positive (%)
Normal control (n = 87)	7 (8)		5 (5.7)		8 (9.2)		4 (4.6)
Tumor differentiation	61 (70.1)		63 (72.4)		58 (66.7)		68 (78.2)
W (n = 30)	22 (75.3)	0.889	22 (75.3)	0.539	14 (46.7)	0.003	18 (60.0)	0.004
M (n = 29)	20 (69.1)		19 (65.6)		19 (65.6)		23 (79.3)
P (n = 28)	19 (67.9)		22 (78.6)		25 (89.3)		27 (96.4)
Depth of invasion
≤ muscularis (n = 37)	18 (48.6)	< 0.001	27 (73.1)	0.92	23 (62.2)	0.002	27 (73.1)	0.314
≥ adventitia (n = 50)	43 (86.0)		36 (72.0)		35 (66.0)		41 (82.0)
LN metastasis
Negative (n = 34)	18 (52.9)	0.005	20 (58.8)	0.023	26 (76.5)	0.12	29 (85.3)	0.197
Positive (n = 53)	43 (81.1)		43 (81.1)		32 (60.3)		39 (73.6)
Ethnic groups
Han (n = 30)	23 (76.7)	> 0.05	22 (73.3)	> 0.05	17 (56.7)	> 0.05	23 (76.7)	> 0.05
Uyghur (n = 25)	18 (72.0)		20 (80.0)		16 (64.0)		20 (80.0)
Kazak (n = 32)	20 (62.5)		21 (65.6)		25 (78.1)		25 (78.1)

All values are presented as the number of cases, with percentages in parentheses. W: Well differentiated; M: Moderately differentiated; P: Poorly differentiated; LN: Lymph node; TLR: Toll-like receptor.