Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice

Figure 4 Magnetic resonance and fluorescent images of a non-enhanced adenoma. A, B: Axial and sagittal pre-enema fluid attenuated inversion recovery (FLAIR) images, note the inner low signal of the mass; C-E: The mass manifests as a filling deficit in the gadopentetate dimeglumine (Gd-DTPA) and fluorescein isothiocyanate-loaded solid lipid nanoparticle (Gd-FITC-SLN) enema inflated FLAIR images; F, G: No enhancement identified after the enema. Note the bladder Gd-DTPA deposition; H: Axial T2 weighted image after the Gd-FITC-SLN enema. Iso-signal observed in the adenoma; high signal observed for the bowel wall; I-K: Hematoxylin and eosin and laser-scanning confocal fluorescence microscope images of the adenoma.