Bimodal visualization of colorectal uptake of nanoparticles in dimethylhydrazine-treated mice

Figure 1 Characterization of solid lipid nanoparticles. A: Gadopentetate dimeglumine and fluorescein isothiocyanate-loaded solid lipid nanoparticles (Gd-FITC-SLNs) freeze-dried powder (1) and dispersion (2); Fluorescein isothiocyanate solid lipid nanoparticles (FITC-SLNs) freeze-dried powder (3) and dispersion (4); B: Atomic force microscopy images of blank solid lipid nanoparticles; C: Magnetic resonance (MR) images of FITC-SLNs dispersions (top). Gd-FITC-SLN suspension (middle). Water (bottom) obtained with fluid attenuated inversion recovery (FLAIR) (left ), T₂WI (middle left ), T₂* GRE (middle right) and PDWI (right). FLAIR was obtained with the following parameters: 2000/11.1/750/2, TR/TE/TI/NEX; T2WI: 3860/106/2 (TR/TE/NEX); T₂* GRE: 550/14/2/200 (TR/TE/NEX/Flip); PDWI: 3220/12/1 (TR/TE/NEX). Both sequences used a 256 × 160 matrix, a 140 mm FOV, and 4-mm-thick sections.