Combined inhibitors of angiogenesis and histone deacetylase: Efficacy in rat hepatoma

doi:10.3748/wjg.v17.i31.3623

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 21, 2011; 17(31): 3623-3629
Published online Aug 21, 2011. doi: 10.3748/wjg.v17.i31.3623

Table 2 Histological analysis of the tissue

	Control 1	PTK/ZK	MS-275	PTK/ZK MS-275	PTK/ZK MS-275 TAM cRA
PCNA pos. cell	44.2 ± 12.4	42.7 ± 9.4	43.7± 5.5	35.1 ± 3.6^a	23.6 ± 3.8^a^c
TUNEL pos. cells	6.9 ± 4.4	11.8 ± 6.6^a	12.2 ± 7.7^a	18.4 ±5.5^c	24.8 ± 10^b^c

^aP < 0.05 vs control 1;

^bP < 0.01 vs control 1;

^cP = 0.01 dual therapy vs quadruple therapy for TdT-mediated dUTP-biotin nick end labeling and proliferating cell nuclear antigen staining. PTK/ZK: PTK787/ZK222584; TAM: Tamoxifen; cRA: 9-cis-retinoic acid; PCNA: Proliferating cell nuclear antigen; TUNEL: TdT-mediated dUTP-biotin nick end labeling.

Citation: Ganslmayer M, Zimmermann A, Zopf S, Herold C. Combined inhibitors of angiogenesis and histone deacetylase: Efficacy in rat hepatoma. World J Gastroenterol 2011; 17(31): 3623-3629
URL: https://www.wjgnet.com/1007-9327/full/v17/i31/3623.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i31.3623