Combined inhibitors of angiogenesis and histone deacetylase: Efficacy in rat hepatoma

Table 1 Extrahepatic tumor burden and side effects in untreated and treated tumor-bearing rats (%)

	Control group (n = 12)	Monotherapy (n = 17)	Combination therapy (n = 24)	P value2
Tumor burden - pulmonary	83.3	82.4	70.8	0.586
Tumor burden - abdominal	91.7	100.0	66.7	0.013
Ascites	83.3	29.4	0.0	< 0.001
Behavior1	41.7	0.0	25.0	0.019
Loss of fur	16.7	41.2	66.7	0.015
Loss of weight (> 10% body weight)	0.0	47.1	79.2	< 0.001
Diarrhea	16.7	29.4	62.5	0.015

¹Reduced food consumption, isolation, stereotypic movements, apathia;

²P values for combined vs single therapy.