Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth

Figure 8 Integrin-linked kinase siRNA inhibits the growth of gastric cancer xenografts in nude mice. BGC-823 cells were treated with integrin-linked kinase (ILK) siRNA or non-silencing siRNA or left untreated. Equal numbers of cells (1 × 10⁷) were injected 48 h later subcutaneously into the armpit of five nude mice in each group. Tumor formation was scored every 3 d. At week 4 after injection, the mice were killed and tumor weight recorded. A: images of tumors excised from the nude mice; B: estimated tumor volume of non-silencing siRNA, untreated or siRNA ILK tumors; C: estimated tumor weights of non-silencing siRNA, untreated or siRNA ILK tumors (^aP < 0.05 vs control).