Integrin-linked kinase in gastric cancer cell attachment, invasion and tumor growth

Figure 6 Effects of integrin-linked kinase on microfilament dynamics of gastric cancer cells. Microfilament organization was assessed by immunofluorescence analysis with rhodamine-phalloidin. A, B: Non-silencing siRNA-transfected cells displayed an elaborate network of precisely organized F-actin filaments and a high degree of cell spreading; C, D: The F-actin filament architecture became significantly disturbed with less lamellipodia and filopodia formation in integrin-linked kinase knockdown cells compared with control cells. Experiments were repeated three times.