Virological response to adefovir monotherapy and the risk of adefovir resistance

Table 1 Baseline characteristics of patients

Variables
No. of patients	77
Age (yr, mean ± SD)	49.3 ± 11.7
Female: Male (n, % male)	18: 59 (77%)
HBeAg positive (n, % positive)	21: 56 (73%)
ALT (U/L, median, range)	119 (25–926)
AST (U/L, median, range)	77 (30–483)
Albumin (g/dL, median, range)	4.0 (2.6–4.6)
Total bilirubin (mg/dL, median, range)	1.0 (0.3–4.0)
Prothrombin time (INR, median, range)	1.1 (0.9–1.7)
Baseline creatinine level (mg/dL, mean ± SD)	0.90 ± 0.13
Creatinine level at weeks 96 (mg/dL, mean ± SD)	0.94 ± 0.16
LAM resistance mutation profile (n, %)
rtM204I ± rtL180M	48 (62%)
rtM204V ± rtL180M	29 (38%)

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; INR: International normalized ratio; LAM: Lamivudine.