Prediction of nephrotoxicity induced by cisplatin combination chemotherapy in gastric cancer patients

Table 2 Pre-acute renal failure (ARF) laboratory data¹ corresponding to renal status post-ARF²

			Renal status of post-ARF		P value3
Variable	Normal range	Unit	Recovered (n = 33)	Unrecovered (n = 8)
Hb	14.0–16.7	g/dL	10.33 ± 1.28 (n = 33)	9.75 ± 0.95 (n = 8)	0.238
HT	14.7–50.7	%	29.88 ± 3.33 (n = 33)	28.56 ± 2.78 (n = 8)	0.307
Protein	6.3–8.3	g/dL	6.792 ± 0.69 (n = 26)	6.429 ± 0.39 (n = 7)	0.191
Albumin	3.5–5.0	g/dL	3.97 ± 0.54 (n = 26)	3.87 ± 0.38 (n = 7)	0.657
BUN	5–23	mg/dL	18.07 ± 5.35 (n = 33)	15.63 ± 4.03 (n = 8)	0.236
SCR	0.3-1.5	mg/dL	1.17 ± 0.20 (n = 33)	1.38 ± 0.13 (n = 8)	0.008
GFR	120-130	mL/min	68.03 ± 13.31 (n = 33)	59.13 ± 6.64 (n = 8)	0.076
Na	136–150	meg/L	139.24 ± 3.19 (n = 33)	140.13 ± 4.09 (n = 8)	0.510
Cl	98–110	meg/L	105.31 ± 4.42 (n = 24)	105.57 ± 3.65 (n = 7)	0.887
K	3.5–5.3	meg/L	4.49 ± 0.46 (n = 8)	4.66 ± 0.65 (n = 8)	0.284
P	3.0–4.5	mg/dL	3.97 ± 0.81 (n = 20)	3.93 ± 1.16 (n = 6)	0.940
Mg	1.6–2.6	mg/dL	2.08 ± 0.26 (n = 24)	2.03 ± 0.29 (n = 7 )	0.635
Ca	8.0-10.0	mg/dL	9.15 ± 0.53 (n = 24)	8.86 ± 0.30 (n = 7)	0.170

¹Pre-acute renal failure (ARF) Laboratory data were checked immediately before the administration of the chemotherapy drug that caused the serum creatinine (SCR) to increase to > 1.5 mg/dL. ²We divided 41 patients into two groups; the recovered group included patients whose SCRs had decreased below 1.5 mg/dL after ARF, the unrecovered group included patients whose SCRs remained greater than 1.5 mg/dL.

³Unpaired Student’s t–test. BUN: Blood urea nitrogen; GFR: Glomerular filtration rate.