Hepatocellular carcinoma xenograft supports HCV replication: A mouse model for evaluating antivirals

Figure 9 Histological evaluation of liver sections after hematoxylin and eosin staining that indicates that interferon-α treatment did not cause any tumor necrosis or reduce the size of tumor nodules in the SCID mice liver. The upper panel shows the untreated mouse liver sections after 2-5 wk of tumor development. The black arrows indicate the hepatocellular carcinoma (HCC) tumor in the mouse liver. Similarly, the lower panel shows the interferon-α-treated mouse liver sections with HCC tumor at different time points (10 × magnification).