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©2011 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 21, 2011; 17(3): 283-289
Published online Jan 21, 2011. doi: 10.3748/wjg.v17.i3.283
Published online Jan 21, 2011. doi: 10.3748/wjg.v17.i3.283
Author | Antiviral therapy | Correlation | Prediction | Clinical results |
Deguchi et al[23] | - | HBV DNA | - | qHBsAg is higher in HBeAg(+) |
Chen et al[28] | - | HBV DNA | - | qHBsAg is higher in HBeAg(+) and high HBV DNA levels, whereas qHBsAg is low in low HBV DNA level CHB |
Werle-Lapostolle et al[29] | ADV | cccDNA, HBV DNA | - | HBsAg and cccDNA decrease with ADV |
Kohmoto et al[30] | LAM | HBV DNA | - | qHBsAg is helpful for early detection of drug resistant strains |
Wursthorn et al[35] | Peg-IFN + ADV | cccDNA | - | Peg-IFN + ADV decreases cccDNA and HBsAg, which are well correlated |
Chan et al[36] | Peg-IFN + LAM | cccDNA | Low baseline qHBsAg can predict SVR | Peg-IFN + LAM decreases cccDNA and HBsAg, which are well correlated |
Manesis et al[31] | IFN vs LAM | HBV DNA | Low baseline qHBsAg can predict SVR | IFN induces sharper decrease in qHBsAg than LAM |
Wiegand et al[27] | FAM ± LAM | HBV DNA (not correlated) | Decline of qHBsAg can predict HBsAg loss | 2 log drop to below 100 IU/mL is associated with HBsAg clearance |
Moucari et al[32] | Peg-IFN | HBV DNA | Early qHBsAg drop can predict SVR | qHBsAg may be useful to optimize Peg-IFN therapy |
Brunetto et al[33] | Peg-IFN ± LAM vs LAM | HBV DNA | On-treatment qHBsAg decline can predict sustained HBsAg loss | qHBsAg < 10 IU/mL at week 48 and 1 log decline predict sustained HBsAg clearance to optimize treatment strategy |
Lau et al[37] | Peg-IFN ± LAM | - | On-treatment qHBsAg can be used as an early predictor of SVR | In HBeAg(+) patients, qHBsAg reduction through weeks 12, 24 and 48 were higher in patients with HBeAg seroconversion |
Marcellin et al[38] | Peg-IFN ± LAM | - | qHBsAg at week 12 can predict long-term HBsAg clearance | 35% of patients who had qHBsAg < 1500 IU/mL at week 12 cleared up HBsAg by 4 yr post-treatment |
Lu et al[39] | Peg-IFN ± LAM | cccDNA | qHBsAg was superior to cccDNA and serum HBV DNA in predicting SVR | Area under ROC curve with qHBsAg, cccDNA and HBV DNA was 0.769, 0.734, and 0.714, respectively, for predicting SVR |
Brunetto et al[65] | Peg-IFN ± LAM | - | On-treatment qHBsAg can be used as an early predictor of SVR | On-treatment decline in HBsAg appears to be genotype dependent. Genotype B patients showed the most rapid and pronounced decline |
Hou et al[66] | Peg-IFN vs LAM | - | - | Peg-IFN was superior to ADV in HBeAg seroconversion and qHBsAg decline in LAM-resistant patients |
- Citation: Lee JM, Ahn SH. Quantification of HBsAg: Basic virology for clinical practice. World J Gastroenterol 2011; 17(3): 283-289
- URL: https://www.wjgnet.com/1007-9327/full/v17/i3/283.htm
- DOI: https://dx.doi.org/10.3748/wjg.v17.i3.283